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Molecular mechanism of the regulation of insect metamorphosis by juvenile hormone eluciated

posted Dec 5, 2015, 6:04 AM by Yukio Ishikawa   [ updated Dec 5, 2015, 3:38 PM ]
Dr. T. Kayukawa Ms. Y. Ito, and Dr. T. Shinoda of the National Institute of Agrobiological Sciences (NIAS), in collaboration with members of our laboratory (K. Nagamine and Y. Ishikawa) and Dr. Y. Nishita of Hokkaido University, have clarified the molecular mechanism of the regulation of insect metamorphosis by juvenile hormone (JH).   It was found that JH directly suppresses the expression of Krüppel homolog 1 (Kr-h1)a gene that suppresses the expression of Broad-complex (BR-C), a master gene that controls the expression of genes specific to the pupal stage. 
  1. Takumi Kayukawa, Keisuke Nagamine, Yuka Ito, Yoshinori Nishita, Yukio Ishikawa, and Tetsuro Shinoda (2015). Krüppel homolog 1 inhibits insect metamorphosis via direct transcriptional repression of Broad-complex, a pupal specifier gene. The Journal of Biological Chemistry.

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