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杉本氏の論文が Faculty of 1000 に選ばれました

2012/02/26 16:46 に Yukio Ishikawa が投稿   [ 2012/03/07 18:09 に Takashi Matsuo さんが更新しました ]
当研究室の特任研究員、杉本博士の論文が Faculty of 1000 (生物学・医学分野) に選ばれました。 Faculty of 1000 は毎月出版される膨大な論文から特に注目すべきもの(約 2%)を厳選して公表し、研究者が読むべき論文を選ぶ際の一つの指標となっています。 F1000メンバーの Nina Wedell 博士によるコメントは次の通りです。
A male-killing Wolbachia carries a feminizing factor and is associated with degradation of the sex-determining system of its host (Biol Lett 2012 Jan 4) 
This intriguing study indicates that male-killing Wolbachia carries a genetic factor that feminizes genetic Ostrinia scapulalis male moths, thereby causing a mismatch between the genetic and phenotypic sex resulting in death. The interaction between genetic and phenotypic sex was determined in normal, infected, and infected-and-cured individuals using a sex-specifically spliced homologue of doublesex (Osdsx) and sex chromatin bodies unique to genetic female moths. This revealed that female spliced Osdsx was expressed in infected male larvae destined to die, whereas the male Osdsx type was expressed in females causing them to die. These results indicate that the male-killing Wolbachia carries a feminizing factor that interferes with the sex-determination system of the host, possibly by affecting the sex-specific splicing of Osdsx. The results also indicate a degradation of the sex-determination system as genetic females cured of infection become masculinized and express the male Osdsx type resulting in death. Taken together, the observed discourse between genetic and phenotypic sexes appears to be responsible for embryonic death and that feminization may in fact underlie male killing in this species. This tentatively hints at common mechanisms potentially underlying the diversity of reproductive manipulations of this endosymbiont.